Abstract: Based on the vertical detonation tube and the radial Hele-Shaw Cell, a set of quasi-two-dimensional cylindrical explosive wave loading device was designed and built in this paper, which can realize the radial impact loading of the material interface inside the Hele-Shaw Cell. The premixed gas inside the vertical detonation tube was ignited to form an upward propagating shock wave, which was reflected by the upper plate of the Hele-Shaw Cell after the diaphragm was broken. Then, a divergent cylindrical wave propagating radially was formed. It was found that the cylindrical shock wave in Hele-Shaw Cell had good repeatability and annular pressure uniformity. The CFD numerical simulation was carried out for the detonation process and the cylindrical wave propagation process inside the Hele-Shaw cell. The law of overpressure attenuation with power function of radial propagation distance was obtained through function fitting, revealing the influence of detonation process inside the detonation tube on the overpressure and impulse distribution inside the Hele-Shaw Cell. It was found that the loading parameters of shock wave in Hele-Shaw Cell can be regulated by adjusting the ignition and detonation process and the initial conditions of premixed gas.