Abstract: In order to evaluate the heat transfer performance of lattice core sandwich structure as well as the possibility of application of that, instead of conventional plate fin structure, within heat exchange system of electric vehicle, in this paper, a series of three-dimensional numerical calculations have been conducted for several typical lattice core sandwich structures, such as kagome lattice structure, tetrahedral lattice structure, pyramidal lattice structure, corrugated plate as well in reference, in terms of their heat transfer performance. For this purpose, the heat transfer coefficients under equal Reynolds number and the Nusselt numbers under equal pumping power were compared. As a result, compared with the corrugated plate, the heat transfer coefficients of these lattice core sandwich structures increase, however, the friction factors of that also achieve a great increase. On the other hand, under the condition of same pumping power, the corrugated plate structure achieves the largest Nusselt number at a lower range of pumping power (< 1 500) because of its almost negligible friction factor. With the increase of pumping power, such as 3 000 W, the Nusselt number of tetrahedral lattice structure gets close to that of corrugated plate and maintains further increasing. This shows its great potential of application within heat exchanger system. A novel structure, which has higher heat transfer performance and lower friction factor, is expected to be used within new type compact heat exchanger system replacing conventional plate fin structure.